8z1v

Structural highlights

Function

DPPB_ECOLI Part of the ABC transporter DppABCDF involved in dipeptide transport (PubMed:7536291). Responsible for the translocation of the substrate across the membrane (Probable).^[1] When a foreign outer membrane heme receptor is expressed in E.coli, DppABCDF can also transport heme and its precursor, 5-aminolevulinic acid (ALA), from the periplasm into the cytoplasm.^{[2] [3]}

References

1. ↑ Abouhamad WN, Manson MD. The dipeptide permease of Escherichia coli closely resembles other bacterial transport systems and shows growth-phase-dependent expression. Mol Microbiol. 1994 Dec;14(5):1077-92. PMID:7536291 doi:10.1111/j.1365-2958.1994.tb01340.x
2. ↑ Létoffé S, Delepelaire P, Wandersman C. The housekeeping dipeptide permease is the Escherichia coli heme transporter and functions with two optional peptide binding proteins. Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12891-6. PMID:16905647 doi:10.1073/pnas.0605440103
3. ↑ Verkamp E, Backman VM, Björnsson JM, Söll D, Eggertsson G. The periplasmic dipeptide permease system transports 5-aminolevulinic acid in Escherichia coli. J Bacteriol. 1993 Mar;175(5):1452-6. PMID:8444807 doi:10.1128/jb.175.5.1452-1456.1993