Structural highlights
9hqm is a 2 chain structure with sequence from Roseiflexus castenholzii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 2.45Å |
| Ligands: | , , , , , |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
TMUUS_ROSCS Catalyzes the conversion of (2E,6E)-farnesyl diphosphate (FPP) into (+)-T-muurolol via a 1,10-cyclization, which requires isomerization of FPP to nerolidyl diphosphate (NPP) and then abstraction of the pyrophosphate from intermediate NPP leading to a (E,Z)-germacradienyl (helminthogermacradienyl) cation.[1] [2] [3]
References
- ↑ Rabe P, Dickschat JS. Rapid chemical characterization of bacterial terpene synthases. Angew Chem Int Ed Engl. 2013 Feb 4;52(6):1810-2. doi: 10.1002/anie.201209103. , Epub 2013 Jan 10. PMID:23307484 doi:http://dx.doi.org/10.1002/anie.201209103
- ↑ Rinkel J, Rabe P, Garbeva P, Dickschat JS. Lessons from 1,3-Hydride Shifts in Sesquiterpene Cyclizations. Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13593-13596. PMID:27666571 doi:10.1002/anie.201608042
- ↑ Rabe P, Schmitz T, Dickschat JS. Mechanistic investigations on six bacterial terpene cyclases. Beilstein J Org Chem. 2016 Aug 15;12:1839-1850. PMID:27829890 doi:10.3762/bjoc.12.173
