Structural highlights
Function
TITIN_MOUSE Key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The size and extensibility of the cross-links are the main determinants of sarcomere extensibility properties of muscle. In non-muscle cells, seems to play a role in chromosome condensation and chromosome segregation during mitosis. Might link the lamina network to chromatin or nuclear actin, or both during interphase.[UniProtKB:Q8WZ42][1] [2]
References
- ↑ Weinert S, Bergmann N, Luo X, Erdmann B, Gotthardt M. M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006 May 22;173(4):559-70. Epub 2006 May 15. PMID:16702235 doi:http://dx.doi.org/jcb.200601014
- ↑ Peng J, Raddatz K, Molkentin JD, Wu Y, Labeit S, Granzier H, Gotthardt M. Cardiac hypertrophy and reduced contractility in hearts deficient in the titin kinase region. Circulation. 2007 Feb 13;115(6):743-51. doi: 10.1161/CIRCULATIONAHA.106.645499., Epub 2007 Jan 29. PMID:17261657 doi:http://dx.doi.org/10.1161/CIRCULATIONAHA.106.645499
