Adenosine A2A receptor
From Proteopedia
FunctionAdenosine A2A receptor (A2AR) is one of the G protein-coupled receptors. The protein uses adenosine as the preferred endogenous agonist and is involved in increasing intracellular cAMP levels.[1] DiseaseA2AR antagonists are being tested in the treatment of Alzheimer's Disease. RelevanceA2AR is responsible for regulating myocardial blood flow. It is involved in cerebral and renal blood flow, immune function, pain regulation and sleep. For details see G protein-coupled receptor. A2AR is blocked by caffeine producing the arousal effect.[2] For details see Caffeine. See also: Structural highlightsLike other G proteins, A2AR has 7 transmembrane helices. 3D Structures of adenosine A2A receptorAdenosine A2A receptor 3D structures
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References
- ↑ Lebon G, Warne T, Edwards PC, Bennett K, Langmead CJ, Leslie AG, Tate CG. Agonist-bound adenosine A(2A) receptor structures reveal common features of GPCR activation. Nature. 2011 May 18. PMID:21593763 doi:10.1038/nature10136
- ↑ Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF. Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens. J Neurosci. 2011 Jul 6;31(27):10067-75. doi: 10.1523/JNEUROSCI.6730-10.2011. PMID:21734299 doi:http://dx.doi.org/10.1523/JNEUROSCI.6730-10.2011
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