Function
Agrin (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. [1]
Relevance
Agr is an inducer of mammalian heart regeneration[2].
Disease
Agr is overexpressed in brains of Alzheimer Disease patients. Agr is associated with myasthenic syndrome.
Structural highlights
Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally. Other Agr domains are: Kazal type serine protease inhibitor.
3D Structures of Agrin
Agrin 3D structures
