Aldose Reductase

From Proteopedia

Contents 1 Function 2 Disease 3 Structural highlights 4 3D Structures of aldose reductase Function Aldose Reductase (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway.[1] Disease The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. Structural highlights AldR structure is of a β/α-barrel. The active site is located in the barrel core.[2] Active site interactions. Water molecules are shown as red spheres. Active site tunnel. 3D Structures of aldose reductase Aldose reductase 3D structures

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References

1. ↑ Rondeau JM, Tete-Favier F, Podjarny A, Reymann JM, Barth P, Biellmann JF, Moras D. Novel NADPH-binding domain revealed by the crystal structure of aldose reductase. Nature. 1992 Jan 30;355(6359):469-72. PMID:1734286 doi:http://dx.doi.org/10.1038/355469a0
2. ↑ Wilson DK, Bohren KM, Gabbay KH, Quiocho FA. An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications. Science. 1992 Jul 3;257(5066):81-4. PMID:1621098