Alprenolol

From Proteopedia

Alprenolol, or alfeprol, alpheprol, and alprenololum (Gubernal, Regletin, Yobir, Apllobal, Aptine, Aptol Duriles), is a non-selective beta blocker as well as a 5-HT1A and 5-HT1B receptor antagonist,[1] used in the treatment of angina pectoris.[2] See also Alprenolol, Adrenergic receptor, and 5-hydroxytryptamine receptor. Human beta2 adrenergic receptor in complex with the neutral antagonist alprenolol (3nya). Alprenolol binding site.

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to enable message translation use jmolSetTranslation(true) prior to jmolApplet() Note -- language translation disabled Jmol getValue popupMenu null Jmol getValue script null Jmol getValue loadInline null Jmol getValue load null Jmol applet jmolApplet1__5172217757858495__ ready script 1 started pdbGetHeader = true FileManager opening url https://proteopedia.org/wiki/extensions/Proteopedia/spt/functions.spt?1733933141 loadScript /wiki/extensions/jsmol/j2s/core/coretext.z.js Loading, please wait ... platformSpeed = 8 FileManager opening url https://proteopedia.org/wiki/scripts/10/1011229/Cv/1.spt      FileManager.getAtomSetCollectionFromFile(https://proteopedia.org/wiki/images/8/89/2035.mol) FileManager opening url https://proteopedia.org/wiki/images/8/89/2035.mol The Resolver thinks Mol 2119 Marvin 12300703363D           2119 pubchem_bondannotations:"10 11 8\n10 13 8\n11 14 8\n13 15 8\n14 16 8\n15 16 8\n4 2 3" stdinchi:"InChI=1S/C15H23NO2/c1-4-7-13-8-5-6-9-15(13)18-11-14(17)10-16-12(2)3/h4-6,8-9,12,14,16-17H,1,7,10-11H2,2-3H3/t14-/m0/s1" stdinchikey:"PAZJSJFMUHDSTF-AWEZNQCLSA-N" auxinfo:"1/0/N:18,8,9,17,16,15,12,14,13,5,7,6,11,4,10,3,2,1/E:(2,3)/it:im/rA:41cOONCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH/rB:;;s2;s3s4;s3;s1s4;s6;s6;s1;s10;s11;d10;d11;s13;s14d15;s12;d17;s4;s5;s5;s6;s3;s7;s7;s8;s8;s8;s9;s9;s9;s2;s12;s12;s13;s14;s15;s16;s17;s18;s18;/rC:-.0799,1.2718,-1.3861;-.378,-1.5116,-.9276;-2.0634,-2.3344,1.357;-1.1699,-.5555,-.2231;-1.4116,-1.0194,1.2322;-2.3108,-2.8096,2.7426;-.4758,.8253,-.186;-3.1587,-4.0977,2.6445;-1.0139,-3.0387,3.5661;.5866,2.3452,-1.5132;2.0077,2.3211,-1.5161;2.7821,1.0454,-1.5223;-.1194,3.567,-1.5487;2.6864,3.5632,-1.4916;.5792,4.7843,-1.5272;1.9837,4.782,-1.4876;2.932,.5178,-2.866;2.4218,-.6356,-3.3093;-2.1225,-.4676,-.7518;-2.019,-.2737,1.7537;-.4342,-1.0704,1.7158;-2.9186,-2.0658,3.2687;-2.9773,-2.2378,.9074;-1.1627,1.5436,.2754;.3962,.7479,.475;-4.0911,-3.9034,2.1102;-3.4172,-4.4653,3.6393;-2.6137,-4.8816,2.1144;-1.2349,-3.4855,4.5361;-.3244,-3.6907,3.0262;-.5024,-2.0971,3.773;.4596,-1.5882,-.4238;3.7857,1.1878,-1.1135;2.3311,.3144,-.847;-1.1435,3.5776,-1.5622;3.7083,3.5956,-1.4717;.065,5.668,-1.5284;2.4923,5.6677,-1.4555;3.4675,1.059,-3.5072;2.5777,-.9274,-4.2456;1.8799,-1.2279,-2.7261;" formula:"C15 H23 N O2" mw:"249.3486" smiles:"O(C1=C([H])C([H])=C([H])C([H])=C1C([H])([H])C([H])=C([H])[H])C([H])([H])[C@]([H])(C([H])([H])[N@]([H])C([H])(C([H])([H])[H])C([H])([H])[H])O[H]" csid:"2035" Time for openFile(https://proteopedia.org/wiki/images/8/89/2035.mol): 452 ms reading 41 atoms ModelSet: haveSymmetry:false haveUnitcells:false haveFractionalCoord:false 1 model in this collection. Use getProperty "modelInfo" or getProperty "auxiliaryInfo" to inspect them. Default Van der Waals type for model set to Babel 41 atoms created ModelSet: not autobonding; use forceAutobond=true to force automatic bond creation manageLoadStructCallback failed TypeError: Cannot read properties of undefined (reading 'replace') Time for creating model: 9 ms loadScript /wiki/extensions/jsmol/j2s/core/corescriptcmd.z.js Standard Hbond calculation 0 hydrogen bonds loadScript /wiki/extensions/jsmol/j2s/J/thread/SpinThread.js Script completed Jmol script terminated spinqualitylabelsall models Alprenolol Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ Elmros T, Hörstedt P, Winblad B. Scanning electron microscopic study of virulent and avirulent colonies of Neisseria gonorrhoeae. Infect Immun. 1975 Sep;12(3):630-7. PMID:809360 doi:10.1128/iai.12.3.630-637.1975
2. ↑ Hickie JB. Alprenolol ("aptin") in angina pectoris. A double-blind multicentre trial. Med J Aust. 1970 Aug 8;2(6):268-72 PMID:4393977