Function
Annexins are proteins which make a membrane scaffold. They bind negatively charged phospholipids and contain a 70 amino acid long annexin repeat. Annexins divide into species and are numbered from I to XII.
- Annexin I is involved in a variety of pathways[1].
- Annexin II is involved in angiogenesis, tutor progression and metastasis[2]. See also Ezetimibe.
- Annexin V is the most abundant scaffolding protein.
- Annexin VI is involved in endocytosis and regulates entry of ligands to prelysosomal compartment[3].
- Annexin VIII is calcium-dependent phospholipid-binding involved in blood coagulation[4].
- Annexin E1 (AnE1) is associated with tubulin in trophozoites of Giardia lamblia and forms local slubs in the flagella.
- Annexin A-V has a major role in coagulation.
Relevance
Annexin I is involved in anti-inflammatory responses and apoptotic mechanisms.
Structural highlights
Annexins consist of 2 domains - the C-terminal core and the N-terminal head. The containing . The core domain concave side contains the .[5]
3D structures of annexin
Annexin 3D structures
