Anti-sigma factor antagonist

From Proteopedia

Jump to: navigation, search

Anti-sigma factor antagonist (SPOIIAA) relieves the inhibition of sigma factor by the anti-sigma factor. The sigma factors (see Sigma factor) are transcriptional regulators whose activity is regulated by anti-sigma factor proteins. The latters are regulated by the anti-sigma factor antagonists.[1]

Structural highlights

  • Biological Assembly of Anti-sigma factor antagonist with anti-sigma factor, Mg+2 ion and ADP.
  • Mg+2 ion and ADP binding site (1th8).[2] Water molecules are shown as red spheres.
  • Anti-sigma factor antagonist contains STAS domain. See STAS domain of the SLC26 anion transporter prestin.

3D Structures of anti-sigma factor antagonist

Anti-sigma factor antagonist 3D structures


Anti-sigma factor antagonist (cyan) complex with anti-sigma factor (magenta), Mg+2 ion and ADP (PDB code 1th8)

Drag the structure with the mouse to rotate

References

  1. Seavers PR, Lewis RJ, Brannigan JA, Verschueren KH, Murshudov GN, Wilkinson AJ. Structure of the Bacillus cell fate determinant SpoIIAA in phosphorylated and unphosphorylated forms. Structure. 2001 Jul 3;9(7):605-14. PMID:11470435
  2. Masuda S, Murakami KS, Wang S, Anders Olson C, Donigian J, Leon F, Darst SA, Campbell EA. Crystal structures of the ADP and ATP bound forms of the Bacillus anti-sigma factor SpoIIAB in complex with the anti-anti-sigma SpoIIAA. J Mol Biol. 2004 Jul 23;340(5):941-56. PMID:15236958 doi:10.1016/j.jmb.2004.05.040

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Personal tools