Function
Atlastin (ATN) is a GTPase and a Golgi body transmembrane protein. ATN was shown to be required in membrane fusion and ER formation in Drosophila melanogaster.[1]
Disease
Defects in the ATN gene are a cause of the degenerative spinal cord disorder spastic paraplegia type 3 and of hereditary sensory neuropathy type 1D. Mutations in ATL-3 affect multiple ER-related pathways[2].
Structural highlights
- from human atlastin (PDB code 4ido).[1] Water molecules shown as red spheres.
3D structures of atlastin
Atlastin 3D structures
