Autophagy-related protein

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Yeast Atg7 C terminal (green) complex with Atg8 (magenta) and Zn+2 ion (grey) (PDB code 3vh3)

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References

  1. Shibutani ST, Saitoh T, Nowag H, Munz C, Yoshimori T. Autophagy and autophagy-related proteins in the immune system. Nat Immunol. 2015 Sep 18;16(10):1014-24. doi: 10.1038/ni.3273. PMID:26382870 doi:http://dx.doi.org/10.1038/ni.3273
  2. Velikkakath AK, Nishimura T, Oita E, Ishihara N, Mizushima N. Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Mol Biol Cell. 2012 Mar;23(5):896-909. doi: 10.1091/mbc.E11-09-0785. Epub 2012, Jan 4. PMID:22219374 doi:http://dx.doi.org/10.1091/mbc.E11-09-0785
  3. Ngu M, Hirata E, Suzuki K. Visualization of Atg3 during autophagosome formation in Saccharomyces cerevisiae. J Biol Chem. 2015 Mar 27;290(13):8146-53. doi: 10.1074/jbc.M114.626952. Epub 2015, Feb 2. PMID:25645919 doi:http://dx.doi.org/10.1074/jbc.M114.626952
  4. Lystad AH, Simonsen A. Mechanisms and Pathophysiological Roles of the ATG8 Conjugation Machinery. Cells. 2019 Aug 25;8(9). pii: cells8090973. doi: 10.3390/cells8090973. PMID:31450711 doi:http://dx.doi.org/10.3390/cells8090973
  5. Matoba K, Kotani T, Tsutsumi A, Tsuji T, Mori T, Noshiro D, Sugita Y, Nomura N, Iwata S, Ohsumi Y, Fujimoto T, Nakatogawa H, Kikkawa M, Noda NN. Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion. Nat Struct Mol Biol. 2020 Oct 26. pii: 10.1038/s41594-020-00518-w. doi:, 10.1038/s41594-020-00518-w. PMID:33106658 doi:http://dx.doi.org/10.1038/s41594-020-00518-w
  6. Zientara-Rytter K, Subramani S. Mechanistic Insights into the Role of Atg11 in Selective Autophagy. J Mol Biol. 2020 Jan 3;432(1):104-122. doi: 10.1016/j.jmb.2019.06.017. Epub 2019 , Jun 22. PMID:31238043 doi:http://dx.doi.org/10.1016/j.jmb.2019.06.017
  7. Kotani T, Kirisako H, Koizumi M, Ohsumi Y, Nakatogawa H. The Atg2-Atg18 complex tethers pre-autophagosomal membranes to the endoplasmic reticulum for autophagosome formation. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10363-10368. doi:, 10.1073/pnas.1806727115. Epub 2018 Sep 25. PMID:30254161 doi:http://dx.doi.org/10.1073/pnas.1806727115
  8. Noda NN, Satoo K, Fujioka Y, Kumeta H, Ogura K, Nakatogawa H, Ohsumi Y, Inagaki F. Structural basis of Atg8 activation by a homodimeric E1, Atg7. Mol Cell. 2011 Nov 4;44(3):462-75. PMID:22055191 doi:10.1016/j.molcel.2011.08.035

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