BRCA

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Contents

Function

BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see:

Disease

Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers[1].

Structural highlights

The phosphopeptide binds at the interface between the BRCT1 and BRCT2 domains. These domains contain most of the mutations seen in BRCA1[2]. Phosphoserine binding.

3D structures of BRCA

BRCA 3D structures


Human BRCA1 BRCT1 and BRCT2 domains complex with phosphopeptide (PDB code 3coj)

Drag the structure with the mouse to rotate

References

  1. ↑ Petrucelli N, Daly MB, Pal T. BRCA1- and BRCA2-Associated Hereditary Breast and Ovarian Cancer PMID:20301425
  2. ↑ Shen Y, Tong L. Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1. Biochemistry. 2008 May 27;47(21):5767-73. Epub 2008 May 2. PMID:18452305 doi:10.1021/bi800314m

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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