BRCA

Function

BRCA1 and BRCA2 or breast cancer type 1 susceptibility protein are tumor suppressors which help repair damaged DNA. For more details see:

• RING Finger Domain of BRCA1 and BARD1 Heterodimer.
• Mutations in BRCA1/BARD1 RING-domain heterodimer.
• Mutations in Brca1 BRCT Domains.

Disease

Mutations in BRAC1 and BRAC2 are associated with increased risk of breast cancer, ovarian cancer and to a lesser extent with other cancers^[1].

Structural highlights

The . These domains contain most of the mutations seen in BRCA1^[2]. .

3D structures of BRCA

BRCA 3D structures