Beta-lactamase
From Proteopedia
FunctionBeta-lactamase (Blac) are enzymes which make bacteria resistant to β-lactam antibiotics by breaking their β-lactam ring. Blac are classified according to their resistance targets.
RelevanceBlac makes some bacteria resistant to antibiotics like penicillin, cephamycin and carbapenems. Structural highlightsThe active site of class B Blac contains 2 Zn+2 ions.[2] See also3D Structures of Beta-lactamase
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References
- ↑ Jacoby GA. AmpC beta-lactamases. Clin Microbiol Rev. 2009 Jan;22(1):161-82, Table of Contents. PMID:19136439 doi:10.1128/CMR.00036-08
- ↑ King D, Strynadka N. Crystal structure of New Delhi metallo-beta-lactamase reveals molecular basis for antibiotic resistance. Protein Sci. 2011 Sep;20(9):1484-91. doi: 10.1002/pro.697. Epub 2011 Aug, 2. PMID:21774017 doi:10.1002/pro.697
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