Beta-secretase 1

From Proteopedia

Jump to: navigation, search

Best example is PDB entry 4ivt and is shown in the viewer.

Contents

Function

Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.Data source: Uniprot P56817

Catalytic Activity

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu-Phe in the Swedish variant of Alzheimer's amyloid precursor protein.Data source: Uniprot P56817

Biological process

Is involved in the following biological processes:
proteolysis

In structures

Beta-secretase 1 is found in 323 PDB entries

3D structure of beta-secretase

See Beta-secretase

Alternative names for Beta-secretase 1

Molecule Beta-secretase 1, also known as Beta-site amyloid precursor protein cleaving enzyme 1, Membrane-associated aspartic protease 2, Aspartyl protease 2, Asp 2, ASP2, Memapsin-2, Beta-secretase 1 and Beta-site APP cleaving enzyme 1.

The best structure for Beta-secretase 1 shown: 4ivt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

PDBe, Michal Harel

Personal tools