Beta Secretase (BACE1) 1SGZ

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Beta-secretase, also known as BACE or Memapsin 2, is encoded by the gene BACE1. Beta-secretase is a proteolytic, transmembrane enzyme with two active sites on the extracellular region. It is associated with processing amyloid precursor protein (APP), which is an integral membrane protein.[1] A malfunction in the processing of APP results in the formation of the peptide amyloid beta. Amyloid-beta is a neurotoxic peptide segment that aggregates into plaques. These plaques are the primary component of plaques found in individuals with Alzheimers Disease. [2] Other biological associations of this enzyme include modulating myelination in the central and peripheral nervous systems.[3]

Human Beta-secretase (PDB 1SGZ)

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  2. 2.0 2.1 2.2 John, V.; Beck, J. P.; Bienkowski, M. J.; Sinha, S.; Heinrikson, R. L. Human β-Secretase (BACE) And BACE Inhibitors. ChemInform. [Online] 2004, 35, 4625-4630.
  3. Hu, X.; Hicks, C. W.; He, W.; Wong, P.; Macklin, W. B.; Trapp, B. D.; Yan, R. Bace1 Modulates Myelination in the Central and Peripheral Nervous System. Nature Neuroscience Nat Neurosci. [Online] 2006, 9, 1520–1525.
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  9. 9.0 9.1 9.2 Golub, M. (Producer) & Golub, M. (Director). (2015). Youtube. United States: University of Rochester Introductory Biochemistry
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  13. Vasser, R. The B-Secretase Enzyme in Alzheimer’s Disease. Journal of Molecular Neurosceince. 2004, 23, 105-113.
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  15. AnaSpec. Amyloid Peptides. Peptides,
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