C-X-C motif chemokine

From Proteopedia

spinqualitylabelsall models CXCL12α dimer complex with sulfate (PDB code 1qg7). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Function 2 Relevance 3 3D Structures of C-X-C motif chemokine Function C-X-C motif chemokine (CXCL) are small chemokines which contain the sequence Cys-X-Cys at their C-terminal. The CXCL are subdivided into 2 groups: ELR positive (containing Glu-Leu-Arg preceding the C-X-C) and ELR negative.[1] • CXCL2 or MIP-2 or imacrophage inflammatory protein 2 acts as chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. • CXCL3 or platelet factor 3 is involved in the development of prostate cancer[2] • CXCL4 or platelet factor 4 is a pro-inflammatory compound[3] • CXCL7 or platelet factor 7 promotes neutrophil adhesion and transmigration[4] • CXCL10 or IP-10 or interferon γ-induced protein 10 acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3[5] • CXCL11 or IP-9 or interferon γ-induced protein 9 acts as chemotactic for activated T cells. • CXCL12 or Stromal-Derived-Factor-1 (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis[6] • CXCL14 or BRAK acts as chemotactic for monocytes and inhibits angiogenesis. Relevance CXCL4 plays an important role in pancreatic inflammation and can be targeted to ameliorate tissue damage in pancreatitis. Levels of CXCL4 are elevated in patients with systemic sclerosis[7]. CXCL12 may be involved in the immune defense pathway during periodontal disease[8]. 3D Structures of C-X-C motif chemokine C-X-C motif chemokine 3D structures

References

1. ↑ Le Y, Zhou Y, Iribarren P, Wang J. Chemokines and chemokine receptors: their manifold roles in homeostasis and disease. Cell Mol Immunol. 2004 Apr;1(2):95-104. PMID:16212895
2. ↑ Xin H, Cao Y, Shao ML, Zhang W, Zhang CB, Wang JT, Liang LC, Shao WW, Qi YL, Li Y, Zhang ZY, Yang Z, Sun YH, Zhang PX, Jia LL, Wang WQ. Chemokine CXCL3 mediates prostate cancer cells proliferation, migration and gene expression changes in an autocrine/paracrine fashion. Int Urol Nephrol. 2018 May;50(5):861-868. doi: 10.1007/s11255-018-1818-9. Epub, 2018 Mar 9. PMID:29524043 doi:http://dx.doi.org/10.1007/s11255-018-1818-9
3. ↑ Wetterholm E, Linders J, Merza M, Regner S, Thorlacius H. Platelet-derived CXCL4 regulates neutrophil infiltration and tissue damage in severe acute pancreatitis. Transl Res. 2016 Oct;176:105-18. doi: 10.1016/j.trsl.2016.04.006. Epub 2016 Apr, 29. PMID:27183218 doi:http://dx.doi.org/10.1016/j.trsl.2016.04.006
4. ↑ Schenk BI, Petersen F, Flad HD, Brandt E. Platelet-derived chemokines CXC chemokine ligand (CXCL)7, connective tissue-activating peptide III, and CXCL4 differentially affect and cross-regulate neutrophil adhesion and transendothelial migration. J Immunol. 2002 Sep 1;169(5):2602-10. doi: 10.4049/jimmunol.169.5.2602. PMID:12193731 doi:http://dx.doi.org/10.4049/jimmunol.169.5.2602
5. ↑ Lee EY, Lee ZH, Song YW. CXCL10 and autoimmune diseases. Autoimmun Rev. 2009 Mar;8(5):379-83. doi: 10.1016/j.autrev.2008.12.002. Epub 2008, Dec 25. PMID:19105984 doi:http://dx.doi.org/10.1016/j.autrev.2008.12.002
6. ↑ Chatterjee M, Gawaz M. Platelet-derived CXCL12 (SDF-1alpha): basic mechanisms and clinical implications. J Thromb Haemost. 2013 Nov;11(11):1954-67. doi: 10.1111/jth.12404. PMID:24024928 doi:http://dx.doi.org/10.1111/jth.12404
7. ↑ van Bon L, Affandi AJ, Broen J, Christmann RB, Marijnissen RJ, Stawski L, Farina GA, Stifano G, Mathes AL, Cossu M, York M, Collins C, Wenink M, Huijbens R, Hesselstrand R, Saxne T, DiMarzio M, Wuttge D, Agarwal SK, Reveille JD, Assassi S, Mayes M, Deng Y, Drenth JP, de Graaf J, den Heijer M, Kallenberg CG, Bijl M, Loof A, van den Berg WB, Joosten LA, Smith V, de Keyser F, Scorza R, Lunardi C, van Riel PL, Vonk M, van Heerde W, Meller S, Homey B, Beretta L, Roest M, Trojanowska M, Lafyatis R, Radstake TR. Proteome-wide analysis and CXCL4 as a biomarker in systemic sclerosis. N Engl J Med. 2014 Jan 30;370(5):433-43. doi: 10.1056/NEJMoa1114576. Epub 2013, Dec 18. PMID:24350901 doi:http://dx.doi.org/10.1056/NEJMoa1114576
8. ↑ Havens AM, Chiu E, Taba M, Wang J, Shiozawa Y, Jung Y, Taichman LS, D'Silva NJ, Gopalakrishnan R, Wang C, Giannobile WV, Taichman RS. Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease. J Periodontol. 2008 May;79(5):845-53. doi: 10.1902/jop.2008.070514. PMID:18454663 doi:http://dx.doi.org/10.1902/jop.2008.070514