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cyclic di-GMP, as found in complex with the diguanylate cyclase PleD 2v0n

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Cyclic di-GMP, (bis-(3'-5') cyclic diguanylic acid)

C-di-GMP is a second messenger that mediates the regulation of cell-surface associated traits in bacteria.

is a cyclic dinucleotide with a 12-membered macro-cycle composed of the the phosphate and ribose moieties. It tends to associate to form with intercalated, stacked bases.

Several protein structures involved in c-di-GMP signaling have been determined (see C-di-GMP signaling).




  • Egli M, Gessner RV, Williams LD, Quigley GJ, van der Marel GA, van Boom JH, Rich A, Frederick CA. Atomic-resolution structure of the cellulose synthase regulator cyclic diguanylic acid. Proc Natl Acad Sci U S A. 1990 Apr;87(8):3235-9. PMID:2158107
  • Guan Y, Gao YG, Liaw YC, Robinson H, Wang AH. Molecular structure of cyclic diguanylic acid at 1 A resolution of two crystal forms: self-association, interactions with metal ion/planar dyes and modeling studies. J Biomol Struct Dyn. 1993 Oct;11(2):253-76. PMID:8286055

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