Function
CAD protein is a trifunctional enzyme which contains dihydroorotase domain (DHO), aspartate transcarbamoylase domain (ATC) and carbamoylphosphate synthetase domain[1]. The CAD protein catalyzes the first 3 of 6 reactions required for pyrimidine biosynthesis.
Disease
Deficiency in carbamoylphosphate synthetase leads to lack of urea and hyperammonemia[2]
Relevance
Structural highlights
The 3D structure of CAD protein dihydroorotase subunit complex with dihydroorotate shows the containing and a flexible loop containing conserved Thr and Phe in a loop-out conformation[3]. Water molecules are shown as red spheres.
3D structures of CAD protein
CAD protein 3D structures
