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Mouse CD44 hyaluronan-binding domain complex with glucuronic acid, NAG and ethylene glycerol (PDB code 2jcq)

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3D structures of CD44

Updated on 02-June-2021

1uuh, 4pz4 – hCD44 hyaluronan-binding domain – human
1poz, 2i83 - hCD44 hyaluronan-binding domain – NMR
4pz3 - hCD44 hyaluronan-binding domain + tetrapeptide
2jcp - mCD44 hyaluronan-binding domain – mouse
2jcq, 2jcr - mCD44 hyaluronan-binding domain + 8-mer HA
4mrd, 4mre, 4mrf, 4mrg, 4mrh, 4np2, , 4np3, 5bzc, 5bzk - mCD44 hyaluronan-binding domain + inhibitor
5bzt, 5bzs, 5bzr, 5bzq, 5bzp, 5bzo, 5bzn, 5bzm, 5bzl, 5bzj, 5bzi, 5bzh, 5bzg, 5bzf, 5bze - mCD44 hyaluronan-binding domain (mutant) + inhibitor
4np3 - mCD44 hyaluronan-binding domain + tetrapeptide


  1. Liu LK, Finzel B. High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction. Acta Crystallogr F Struct Biol Commun. 2014 Sep 1;70(Pt 9):1155-61. doi:, 10.1107/S2053230X14015532. Epub 2014 Aug 29. PMID:25195884 doi:
  2. Banerji S, Wright AJ, Noble M, Mahoney DJ, Campbell ID, Day AJ, Jackson DG. Structures of the Cd44-hyaluronan complex provide insight into a fundamental carbohydrate-protein interaction. Nat Struct Mol Biol. 2007 Mar;14(3):234-9. Epub 2007 Feb 11. PMID:17293874 doi:10.1038/nsmb1201

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