CFTR inhibitory factor

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CFTR inhibitory factor complex with an intermediate (PDB code 5tnh)

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3D structures of CFTR inhibitory factor

Updated on 07-May-2020

3kd2 - PaCif - Pseudomonas aeruginosa
3kda, 4dm7, 4dln, 4dmf, 4dmh, 4dmk, 3pi6, 4dmc - PaCif (mutant)
5tnh, 5tng, 5tni, 5tnl, 5tnk, 5tnn, 5tnm, 5tnd, 5tnf, 5tne, 5tnp, 5tnr, 5tnq, 5tns, 5tnj, 5jyc, 4dno, 4dnf - PaCif (mutant) + intermediate
4ehb - PaCif (mutant) + epoxyhexane
4eus - PaCif + hexanediol
4yx9, 5hka, 5hkb, 5hk9 - PaCif + inhibitor


  1. Bahl CD, Hvorecny KL, Bomberger JM, Stanton BA, Hammock BD, Morisseau C, Madden DR. Inhibiting an epoxide hydrolase virulence factor from Pseudomonas aeruginosa protects CFTR. Angew Chem Int Ed Engl. 2015 Jul 1. doi: 10.1002/anie.201503983. PMID:26136396 doi:
  2. Hvorecny KL, Bahl CD, Kitamura S, Lee KSS, Hammock BD, Morisseau C, Madden DR. Active-Site Flexibility and Substrate Specificity in a Bacterial Virulence Factor: Crystallographic Snapshots of an Epoxide Hydrolase. Structure. 2017 May 2;25(5):697-707.e4. doi: 10.1016/j.str.2017.03.002. Epub 2017, Apr 6. PMID:28392259 doi:

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