Calcium ions the Gla domain

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The Gla domain of factors IX and X . A, the numbering at the top refers to sequences of bovine (b) factors IX and X, and the numbering at the bottom refers to sequences of human (h) factors IX and X. Gla residues are represented by and colored in red. The black and red arrows above the residues indicate the coordinating Ca2+ and Mg2+ ions, respectively. The yellow columns represent the putative sites on the membrane for the insertion of hydrophobic residues.
The Gla domain of factors IX and X [1]. A, the numbering at the top refers to sequences of bovine (b) factors IX and X, and the numbering at the bottom refers to sequences of human (h) factors IX and X. Gla residues are represented by and colored in red. The black and red arrows above the residues indicate the coordinating Ca2+ and Mg2+ ions, respectively. The yellow columns represent the putative sites on the membrane for the insertion of hydrophobic residues.


References

  1. ↑ Shikamoto Y, Morita T, Fujimoto Z, Mizuno H. Crystal structure of Mg2+- and Ca2+-bound Gla domain of factor IX complexed with binding protein. J Biol Chem. 2003 Jun 27;278(26):24090-4. Epub 2003 Apr 14. PMID:12695512 doi:10.1074/jbc.M300650200

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Nadia Dorochko

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