Carbamazepine

From Proteopedia

Carbamazepine, sold under the brand name Tegretol among others, is an anticonvulsant medication used in the treatment of epilepsy and neuropathic pain.[1][2] It is used as an adjunctive treatment in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][2] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalized seizures.[4] It is not effective for absence or myoclonic seizures.[2] See also Carbamazepine. Carbamazepine is a sodium channel blocker.[5] It binds preferentially to voltage-gated sodium channels (Nav) in their inactive conformation, which prevents repetitive and sustained firing of an action potential. Nav1.7 with Carbamazepine (8s9c). Carbamazepine binding site.

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References

1. ↑ "Tegretol - carbamazepine suspension Tegretol - carbamazepine tablet Tegretol XR- carbamazepine tablet, extended release". DailyMed. 16 May 2022. Retrieved 3 January 2023.
2. ↑ ^{2.0 2.1 2.2} "Carbamazepine". The American Society of Health-System Pharmacists. Archived from the original on 27 February 2015. Retrieved 28 March 2015.
3. ↑ Nevitt SJ, Marson AG, Weston J, Tudur Smith C. Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. Cochrane Database Syst Rev. 2018 Aug 9;8(8):CD001769. PMID:30091458 doi:10.1002/14651858.CD001769.pub4
4. ↑ Nevitt SJ, Marson AG, Tudur Smith C. Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review. Cochrane Database Syst Rev. 2019 Jul 18;7(7):CD001911. PMID:31318037 doi:10.1002/14651858.CD001911.pub4
5. ↑ Rogawski MA, Löscher W, Rho JM. Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet. Cold Spring Harb Perspect Med. 2016 May 2;6(5):a022780. PMID:26801895 doi:10.1101/cshperspect.a022780