Cathepsin k

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Human Cathepsin K

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References

  1. 1.0 1.1 1.2 Kafienah W, Bromme D, Buttle DJ, Croucher LJ, Hollander AP. Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix. Biochem J. 1998 May 1;331 ( Pt 3):727-32. PMID:9560298
  2. 2.0 2.1 2.2 2.3 2.4 Arav VI, Slesarev SM, Slesareva EV. A method for extirpation of the pineal gland in albino rats. Bull Exp Biol Med. 2008 Sep;146(3):382-4. PMID:19240866 doi:doi
  3. 3.0 3.1 3.2 3.3 3.4 Turk V, Stoka V, Vasiljeva O, Renko M, Sun T, Turk B, Turk D. Cysteine cathepsins: from structure, function and regulation to new frontiers. Biochim Biophys Acta. 2012 Jan;1824(1):68-88. doi: 10.1016/j.bbapap.2011.10.002. , Epub 2011 Oct 12. PMID:22024571 doi:http://dx.doi.org/10.1016/j.bbapap.2011.10.002
  4. 4.0 4.1 4.2 4.3 4.4 Stoch SA, Wagner JA. Cathepsin K inhibitors: a novel target for osteoporosis therapy. Clin Pharmacol Ther. 2008 Jan;83(1):172-6. Epub 2007 Dec 12. PMID:18073778 doi:http://dx.doi.org/10.1038/sj.clpt.6100450
  5. 5.0 5.1 5.2 Vaananen K. Mechanism of osteoclast mediated bone resorption--rationale for the design of new therapeutics. Adv Drug Deliv Rev. 2005 May 25;57(7):959-71. Epub 2005 Apr 15. PMID:15876398 doi:http://dx.doi.org/10.1016/j.addr.2004.12.018
  6. 6.0 6.1 6.2 6.3 6.4 Littlewood-Evans AJ, Bilbe G, Bowler WB, Farley D, Wlodarski B, Kokubo T, Inaoka T, Sloane J, Evans DB, Gallagher JA. The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma. Cancer Res. 1997 Dec 1;57(23):5386-90. PMID:9393764
  7. 7.0 7.1 7.2 7.3 7.4 Zhao B, Janson CA, Amegadzie BY, D'Alessio K, Griffin C, Hanning CR, Jones C, Kurdyla J, McQueney M, Qiu X, Smith WW, Abdel-Meguid SS. Crystal structure of human osteoclast cathepsin K complex with E-64. Nat Struct Biol. 1997 Feb;4(2):109-11. PMID:9033588
  8. 8.0 8.1 8.2 8.3 Chapman HA, Riese RJ, Shi GP. Emerging roles for cysteine proteases in human biology. Annu Rev Physiol. 1997;59:63-88. PMID:9074757 doi:http://dx.doi.org/10.1146/annurev.physiol.59.1.63
  9. 9.0 9.1 McQueney MS, Amegadzie BY, D'Alessio K, Hanning CR, McLaughlin MM, McNulty D, Carr SA, Ijames C, Kurdyla J, Jones CS. Autocatalytic activation of human cathepsin K. J Biol Chem. 1997 May 23;272(21):13955-60. PMID:9153258
  10. 10.0 10.1 Bossard MJ, Tomaszek TA, Thompson SK, Amegadzie BY, Hanning CR, Jones C, Kurdyla JT, McNulty DE, Drake FH, Gowen M, Levy MA. Proteolytic activity of human osteoclast cathepsin K. Expression, purification, activation, and substrate identification. J Biol Chem. 1996 May 24;271(21):12517-24. PMID:8647860
  11. . UniProt: a hub for protein information. Nucleic Acids Res. 2015 Jan;43(Database issue):D204-12. doi: 10.1093/nar/gku989. , Epub 2014 Oct 27. PMID:25348405 doi:http://dx.doi.org/10.1093/nar/gku989
  12. 12.0 12.1 12.2 12.3 Artimo P, Jonnalagedda M, Arnold K, Baratin D, Csardi G, de Castro E, Duvaud S, Flegel V, Fortier A, Gasteiger E, Grosdidier A, Hernandez C, Ioannidis V, Kuznetsov D, Liechti R, Moretti S, Mostaguir K, Redaschi N, Rossier G, Xenarios I, Stockinger H. ExPASy: SIB bioinformatics resource portal. Nucleic Acids Res. 2012 Jul;40(Web Server issue):W597-603. doi:, 10.1093/nar/gks400. Epub 2012 May 31. PMID:22661580 doi:http://dx.doi.org/10.1093/nar/gks400
  13. 13.0 13.1 Garnero P, Borel O, Byrjalsen I, Ferreras M, Drake FH, McQueney MS, Foged NT, Delmas PD, Delaisse JM. The collagenolytic activity of cathepsin K is unique among mammalian proteinases. J Biol Chem. 1998 Nov 27;273(48):32347-52. PMID:9822715
  14. Shaw KL, Grimsley GR, Yakovlev GI, Makarov AA, Pace CN. The effect of net charge on the solubility, activity, and stability of ribonuclease Sa. Protein Sci. 2001 Jun;10(6):1206-15. PMID:11369859 doi:http://dx.doi.org/10.1110/ps.440101
  15. 15.0 15.1 15.2 15.3 15.4 Hou WS, Li Z, Gordon RE, Chan K, Klein MJ, Levy R, Keysser M, Keyszer G, Bromme D. Cathepsin k is a critical protease in synovial fibroblast-mediated collagen degradation. Am J Pathol. 2001 Dec;159(6):2167-77. PMID:11733367 doi:http://dx.doi.org/10.1016/S0002-9440(10)63068-4
  16. 16.0 16.1 Diaz A, Willis AC, Sim RB. Expression of the proteinase specialized in bone resorption, cathepsin K, in granulomatous inflammation. Mol Med. 2000 Aug;6(8):648-59. PMID:11055584
  17. 17.0 17.1 17.2 17.3 17.4 17.5 17.6 Lindstedt L, Lee M, Oorni K, Bromme D, Kovanen PT. Cathepsins F and S block HDL3-induced cholesterol efflux from macrophage foam cells. Biochem Biophys Res Commun. 2003 Dec 26;312(4):1019-24. PMID:14651973
  18. Asagiri M, Hirai T, Kunigami T, Kamano S, Gober HJ, Okamoto K, Nishikawa K, Latz E, Golenbock DT, Aoki K, Ohya K, Imai Y, Morishita Y, Miyazono K, Kato S, Saftig P, Takayanagi H. Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science. 2008 Feb 1;319(5863):624-7. doi: 10.1126/science.1150110. PMID:18239127 doi:http://dx.doi.org/10.1126/science.1150110
  19. 19.0 19.1 Gelb BD, Shi GP, Chapman HA, Desnick RJ. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency. Science. 1996 Aug 30;273(5279):1236-8. PMID:8703060

Content Donors

Hamed Aldhahri, Casey Bartel, Stuart Harris, Luke Parry, Lauren Sharpe, and Allison Weinschreider contributed to the research of cathepsin K presented in the article.

Proteopedia Page Contributors and Editors (what is this?)

Lauren Sharpe, Michal Harel, Alexander Berchansky

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