Function
Cellobiohydrolase (CBH) is a cellulase which degrades cellulose by hydrolysing the 1,4-β-D-glycosidic bonds. CBH is an exocellulase which cleaves two to four units from the ends of cellulose. There are two types of CBH. CBHI cleaves progressively from the reducing end while CBHII cleaves progressively from the nonreducing end of cellulose.[1]. The exo-acting CBH I is called Cel7A. The endo-acting CBH I is called Cel7B. Cellobiohydrolase Cel6A contains an active site within a tunnel which opens and closes in response to ligand binding[2].
Structural highlights
The of CBH contains (Gln-Asp-Glu in 3cel, cyan) and is situated at the .[3] Water molecules shown as red spheres.
3D structures of cellobiohydrolase
Cellobiohydrolase 3D structures
