Chitinase-3-like protein

From Proteopedia

Chitinase-3-like protein 1 (YKL-40) or Gp39 or cartilage glycoprotein-39 has a role as an autoantigen in rheumatoid arthritis. See also Diabetes & Hypoglycemia and Inflammation & Rheumatoid Arthritis. The goat, sheep, bovine signaling protein is termed SPG-40, SPS-40 and SPC-40, respectively. For details see Molecular Playground/YKL-40 and YKL-40. Chitin tetramer binding site (water molecules are shown as red spheres; 1hjv).[1] Relevance Chitinase-3-like protein 1 and Chitinase-3-like protein 2 show strong expression in brain of multiple sclerosis patients and might help define the stage of the disease and have a prognostic value[2]. 3D Structures of chitinase-3-like protein Chitinase-3-like protein 3D structures

spinqualitylabelsall models Glycosylated chitinase-3-like protein 1 tetramer complex with chitin tetramer and sulfate, (PDB code 1hjv) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

References

1. ↑ Houston DR, Recklies AD, Krupa JC, van Aalten DM. Structure and ligand-induced conformational change of the 39-kDa glycoprotein from human articular chondrocytes. J Biol Chem. 2003 Aug 8;278(32):30206-12. Epub 2003 May 29. PMID:12775711 doi:10.1074/jbc.M303371200
2. ↑ Hinsinger G, Galeotti N, Nabholz N, Urbach S, Rigau V, Demattei C, Lehmann S, Camu W, Labauge P, Castelnovo G, Brassat D, Loussouarn D, Salou M, Laplaud D, Casez O, Bockaert J, Marin P, Thouvenot E. Chitinase 3-like proteins as diagnostic and prognostic biomarkers of multiple sclerosis. Mult Scler. 2015 Sep;21(10):1251-61. doi: 10.1177/1352458514561906. Epub 2015 Feb, 19. PMID:25698171 doi:http://dx.doi.org/10.1177/1352458514561906