Choline O-acetyltransferase

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Human choline O-acetyltransferase complex with choline (PDB entry 2fy3)

3D Structures of choline O-acetyltransferase

Updated on 07-June-2021

2fy2 – hChaT – human

2fy3 – hChaT + choline

2fy4 – hChaT + CoA

2fy5 – hChaT + CoA derivative
7amd - hChaT + pyridine derivative
1q6x, 1t1u – ChaT – rat


  1. Dobransky T, Rylett RJ. Functional regulation of choline acetyltransferase by phosphorylation. Neurochem Res. 2003 Apr;28(3-4):537-42. PMID:12675142
  2. Oda Y. Choline acetyltransferase: the structure, distribution and pathologic changes in the central nervous system. Pathol Int. 1999 Nov;49(11):921-37. PMID:10594838
  3. Maselli RA, Chen D, Mo D, Bowe C, Fenton G, Wollmann RL. Choline acetyltransferase mutations in myasthenic syndrome due to deficient acetylcholine resynthesis. Muscle Nerve. 2003 Feb;27(2):180-7. doi: 10.1002/mus.10300. PMID:12548525 doi:
  4. Hawley WR, Witty CF, Daniel JM, Dohanich GP. Choline acetyltransferase in the hippocampus is associated with learning strategy preference in adult male rats. Behav Brain Res. 2015 Aug 1;289:118-24. doi: 10.1016/j.bbr.2015.04.034. Epub 2015, Apr 27. PMID:25930215 doi:
  5. Vijayaraghavan S, Karami A, Aeinehband S, Behbahani H, Grandien A, Nilsson B, Ekdahl KN, Lindblom RP, Piehl F, Darreh-Shori T. Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway. PLoS One. 2013 Jun 19;8(6):e65936. doi: 10.1371/journal.pone.0065936. Print 2013. PMID:23840379 doi:
  6. Kim AR, Rylett RJ, Shilton BH. Substrate binding and catalytic mechanism of human choline acetyltransferase. Biochemistry. 2006 Dec 12;45(49):14621-31. PMID:17144655 doi:10.1021/bi061536l

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