Conformation-specific anti-Factor IX antibodies

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Image:glaOmagaP3.jpg

Crystal structure of the complex of the 10C12 Fab and Factor IX-(1-47)[1]. A ribbon diagram depicts the Fab fragment of the antibody 10C12. Light chain is shown in light blue, and heavy chain is shown in dark blue. Factor IX-(1-47) is also shown as a ribbon diagram, colored blue to yellow from the N terminus to the C terminus. Six calcium ions are shown from Ca-1 to Ca-7. Ca-6 is not present in this structure. Residues 1, 5, 6, 9, 11, and 45 in Factor IX-(1-47) are labeled. The side chains of residues 5, 6, 9, and 11 are included.

Additional Resources

For additional information, see: Hemophilia

References

  1. ↑ Huang M, Furie BC, Furie B. Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. J Biol Chem. 2004 Apr 2;279(14):14338-46. Epub 2004 Jan 13. PMID:14722079 doi:10.1074/jbc.M314011200

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Nadia Dorochko, David Canner

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