Function
Crystallin is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it. α-, β-, γ-, δ-crystallin are named according to the order they are eluted by gel filtration.
- Alpha crystallin has chaperone-like properties like the ability to prevent precipitation of denatured proteins[1]. See Alpha crystallin.
- Gamma crystallin is found mainly in the nuclear region of the lens[2].
- . δ-crystallin is found in avian and reptilian lenses and missing from fish, amphibia and mammals lenses[3].
Disease
Mutations in α-A-crystallin and α-B-crystallin can cause myopathy[4]. Several human cataracts have been linked to mutations in γ-D-crystallin[5].
3D Structures of Crystallin
Crystallin 3D structures
