Function
D-alanine-D-alanine ligase (DDL) catalyzes the conversion of 2 alanine molecules and ATP to D-alanine-D-alanine and ADP. DDL is part of the bacterial peptidoglycan synthesis pathway and the alanine metabolism.[1]
Relevance
DDL acts in bacterial cell wall synthesis and its inhibition is a target of novel antibiotics search.
Structural highlights
DDL structure contains (Alpha Helices, Beta Strands , Loops , Turns). The is found between domains 1 and 2.[2]
3D structures of D-alanine-D-alanine ligase
D-alanine-D-alanine ligase 3D structures
