DNA Repair

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The discussion on this page is targeted at genetics students, so familiarity with DNA structure, DNA Replication and Basics of Protein Structure is assumed.

DNA repair is necessary to maintain genome fidelity. Errors in DNA can arise from many different sources. Errors introduced in the replication process are the simplest source. This leads to non-Watson-Crick base pairs and local distortions in the helix. Bases can also be damaged by oxidizing agents, alkylating agents or UV light. This page will discuss different strategies for repairing these types of DNA damage. Click the green links to see depictions that match the words.

MutH complex with DNA, AMP derivative and Ca+2 ion (PDB id 2aor)

Drag the structure with the mouse to rotate

For more structures, please see DNA Replication, Repair, and Recombination


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