DNA damage-binding protein

From Proteopedia

Function

DNA damage-binding protein (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. DDB is a heterodimer composed of the large DDB1 and the smaller DNA-binding DDB2.

DNA in this complex with DDB1 and DDB2 contains modified compounds 5PY and 64T (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.^[1]
Water molecules shown as red spheres.

Disease

Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity.

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Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code 3ei1).

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3D Structures of DNA damage-binding protein

Updated on 30-January-2023

DDB1

DDB1 binary complex

DDB1 ternary complex

DDB1 quaternary complex

DDB1+DDB2

References

↑ Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapic-Otrin V. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. Cancer Res. 2008 Jul 1;68(13):5014-22. PMID:18593899 doi:68/13/5014