DNA damage-binding protein

Function

DNA damage-binding protein (DDB) functions in nucleotide excision repair. It prevents UV damage to DNA. .

DNA in this complex with DDB1 and DDB2 contains modified compounds (in darkmagenta and magenta, respectively), they are derivatives from parent compound THYMIDINE-5'-MONOPHOSPHATE.^[1]
Water molecules shown as red spheres.

Disease

Defective activity of DDB2 causes the repair defects in patients with XPE - an autosomal disorder characterized by early onset of cancer and photosensitivity.