Function
Dihydroorotase (DHO) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate in the pyrimidine biosynthesis pathway[1].
Relevance
The difference between bacterial and mammalian DHO makes it a promising drug target[2].
Structural highlights
The 3D structure of the complex of DHO with dihydroorotate and carbamoyl aspartate shows these contacts includes electrostatic interactions. Water molecules are shown as red spheres. The substrate [3].
3D structures of dihydroorotase
Dihydroorotase 3D structures
