From Proteopedia

Jump to: navigation, search

The structure of chlorothiazide bound to glutamate receptor 2 complex with glutamate and Zn+2 ion (grey) (PDB code 3ik6)

Drag the structure with the mouse to rotate


  1. 1.0 1.1 EMBL-EBI. (2012) 6-chloro-3,4-dihydro-2H-1, 2, 4-benzothiadiazine-7-sulfonamide-1, 1-dioxide, Protein Data Bank in Europe. Retrieved from http://www.ebi.ac.uk/pdbe/entry/pdb/3ik6/bound/HCZ
  2. Royal Society of Chemistry. (2015) Hydrochlorothiazide, ChemSpider. Retrieved from http://www.chemspider.com/Chemical-Structure.3513.html
  3. 3.0 3.1 EMBL-EBI. (2012) Crystal structure of the AMPA subunit GluR2 bound to the allosteric modulator, chlorothiazide, Protein Data Bank in Europe. Retrieved from http://www.ebi.ac.uk/pdbe/entry/pdb/3ik6
  4. Nasim, A. (2017) Synthesis of chlorothiazide, Medical Chemistry Lecture Notes. Retrieved from http://medicinal-chemistry-notes.blogspot.com/2015/12/synthesis-of-chlorothiazide.html#
  5. 5.0 5.1 The Metabolomics Innovation Centre. (2016) Chlorothiazide, DrugBank. Retrieved from https://www.drugbank.ca/drugs/DB00880
  6. Freis, E., Wanko, A., Wilson, I., and Parrish, A.E. (1985) Treatment of essential diabetes with Chlorothiazide (Diuril), J. Am. Med. Assoc 166, 137-140
  7. Greene, J.A. (2005) Releasing the flood waters: diuril and the reshaping of hypertension, Bull. Hist. Med. 79, 749-794.
  8. 8.0 8.1 Drug.com. (2017) Diuril, Drugs.com. Retrieved from https://www.drugs.com/pro/diuril.html
  9. RxList Inc. (2017) Medical definition of diuretic, RxList: The Internet Drug Index. Retrieved from http://www.rxlist.com/script/main/art.asp?articlekey=7103
  10. Crawford, J.D., Kennedy, G.C., and Hill, L.E. (1960) Clinical results of treatment of diabetes insipidus with drugs of the chlorothiazide series, N. Engl. J. Med. 262, 737-743.
  11. 11.0 11.1 Simon, H. and Zieve, D. (2012) Kidney stones, University of Maryland Medical Center. Retrieved from http://umm.edu/health/medical/reports/articles/kidney-stones
  12. AHFS Patient Medication Information. (2017) Chlorothiazide, U.S. National Library of Medicine. Retrieved from https://medlineplus.gov/druginfo/meds/a682341.html
  13. The Mayo Clinic Staff. (2017) Idiopathic thrombocytopenic purpura (ITP), Mayo Clinic. Retrieved from http://www.mayoclinic.org/diseases-conditions/idiopathic-thrombocytopenic-purpura/symptoms-causes/dxc-20201224
  14. Jaffe, M.O. and Kierland, R. R. (1958) purpura due to chlorothiazide (Diuril), J. Am. Med. Assoc. 168, 2264-2265.

Proteopedia Page Contributors and Editors (what is this?)

Heather D. McKay, Alexander Berchansky, Joel L. Sussman, Michal Harel

Personal tools