Function
Dynamin (DNM) is a GTPase which mediates endocytosis in membrane scission[1] and organelle division. Dynamin 1-like mediates outer mitochondrial membrane fission[2]. DNM is a multidomain GTPase. Mammalian genomes contain 3 DNM genes which show ca. 80% homology. DNM 1 is localized to neurons, DNM 2 is expressed ubiquitously and DNM 3 is found predominantly in the brain[3]. The DNM 1 domain structure includes GTPase, middle, Plextrin homology, GTPase effector and proline- and arginine-rich (PRD) domains.
Disease
Mutations in DNM-2 cause centronuclear myopathy[4].
Structural highlights
The GTPase domain of DNM 1 contains several nucleotide binding motifs which interact with the bound GDP. residues 38-45; residues 205-208; reidues 236-246[5]. Water molecules are shown as red spheres. .
Dynamin 3D structures
See Dynamin 3D structures