Function
Ephrin receptors (EPHR) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin[1]. For more details see Ephrin Type-A Receptor and Kinase-linked, enzyme-linked and related receptors.
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Relevance
EPHR and ephrins can act as both tumor suppressors and tumor enhancers depending on the context[2].
Structural highlights
EPHR domains include an ectodomain (residues 23-435) containing the LBD (residues 23-326), a second fibronectin III domain (fn3) (residues 446-539), a transmembrane domain (residues 539-563), a kinase domain (residues 596-900) and a sterile-α-motif (SAM) domain (residues 908-972).
. Water molecules are shown as red spheres.
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(3fxx).[3]
3D Structures of ephrin receptor
Ephrin receptor 3D structures
