Epidermal Growth Factor Receptor

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Glycosylated EGFR (PDB code 3i2t)

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Additional Resources

For additional information, see: Cancer


  1. D'Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, Weisinger K, Bassat E, Rajchman D, Yifa O, Lysenko M, Konfino T, Hegesh J, Brenner O, Neeman M, Yarden Y, Leor J, Sarig R, Harvey RP, Tzahor E. ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation. Nat Cell Biol. 2015 May;17(5):627-38. doi: 10.1038/ncb3149. Epub 2015 Apr 6. PMID:25848746 doi:http://dx.doi.org/10.1038/ncb3149
  2. 2.0 2.1 Sherrill JM, Kyte J. Activation of epidermal growth factor receptor by epidermal growth factor. Biochemistry. 1996 May 7;35(18):5705-18. doi: 10.1021/bi9602268. PMID:8639530 doi:http://dx.doi.org/10.1021/bi9602268
  3. 3.0 3.1 Herbst RS. Review of epidermal growth factor receptor biology. Int J Radiat Oncol Biol Phys. 2004;59(2 Suppl):21-6. doi:, 10.1016/j.ijrobp.2003.11.041. PMID:15142631 doi:http://dx.doi.org/10.1016/j.ijrobp.2003.11.041
  4. 4.00 4.01 4.02 4.03 4.04 4.05 4.06 4.07 4.08 4.09 4.10 Pao W, Miller V, Zakowski M, Doherty J, Politi K, Sarkaria I, Singh B, Heelan R, Rusch V, Fulton L, Mardis E, Kupfer D, Wilson R, Kris M, Varmus H. EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13306-11. doi:, 10.1073/pnas.0405220101. Epub 2004 Aug 25. PMID:15329413 doi:http://dx.doi.org/10.1073/pnas.0405220101
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