Function
Hydroxypropylphosphonic acid epoxidase (HppE) is involved in the biosynthesis of the antibiotic fosfomycin[1]. HppE is a Zn+2/Fe+2-dependent enzyme. Halohydrin epoxidase (HHE) is involved in the degradation of halohydrins by the displacement of a halogen in halohydrins to produce the epoxide[2].
Relevance
Fosfomycin is an antibiotic produced by some Streptomyces species.
Structural highlights
The . The enzyme uses an induced-fit mechanism to protect high-energy iron-oxygen species formed during catalysis by moving a to seal off the top portion of the active site[3]. .
3D structures of epoxidase
Epoxidase 3D structures