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Yeast epsin-2 ENTH complex with PIP2 and sulfate (PDB code 5on7)

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3D structures of epsin

Updated on 23-February-2023

1inz - hEps epsin N-terminal homology domain ENTH 1-144 - human NMR
1xgw, 2qy7 - hEps-4 ENTH domain
1edu, 1eyh - rEps-1 ENTH domain - rat
1h0a - rEps ENTH domain + inositol triphosphate
5lp0 - Eps-1 ENTH domain - zebrafish
5onf, 5loz - yEps-1 ENTH domain - yeast
5ahv, 7b2l - yEps-1 ENTH domain + SLA2 ANTH domain - Cryo EM
6enr, 4gzc - yEps-2 ENTH domain
4gzd - yEps-2 ENTH domain (mutant)
5on7 - yEps-2 ENTH domain + PIP2
3onk - yEps-3 ENTH domain
3onl - yEps-3 ENTH domain + T-SNARE VTII HABC domain
5j08, 5cmw, 5cmy - yEps-5 ENTH domain
5oo7 - Eps-2 ENTH domain + PIP2 – Chaetomium thermophilum


  1. Sen A, Madhivanan K, Mukherjee D, Aguilar RC. The epsin protein family: coordinators of endocytosis and signaling. Biomol Concepts. 2012 Apr;3(2):117-126. doi: 10.1515/bmc-2011-0060. PMID:22942912 doi:http://dx.doi.org/10.1515/bmc-2011-0060
  2. Chang B, Tessneer KL, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy ML, Rahman R, Ma JX, Xia L, Chen H. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun. 2015 Mar 16;6:6380. doi: 10.1038/ncomms7380. PMID:25871009 doi:http://dx.doi.org/10.1038/ncomms7380
  3. Garcia-Alai MM, Heidemann J, Skruzny M, Gieras A, Mertens HDT, Svergun DI, Kaksonen M, Uetrecht C, Meijers R. Epsin and Sla2 form assemblies through phospholipid interfaces. Nat Commun. 2018 Jan 23;9(1):328. doi: 10.1038/s41467-017-02443-x. PMID:29362354 doi:http://dx.doi.org/10.1038/s41467-017-02443-x

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