Exportins (XPO) or chromosomal maintenance protein mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates.
- XPO-1 mediates nuclear transport of cellular proteins bearing a Leu-rich nuclear export signal and of RNA.
- XPO-4 mediates nuclear transport of eukaryotic translation initiation factor 5A[1].
- XPO-4 mediates nuclear transport of pre-miroRNAs and short hairpin RNAs[2].
- XPO-t exports tRNA from the nucleus[3].
Structural highlights
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(PDB code 3icq).[4]
3D structures of exportin
Exportin 3D structures
