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FMDV 3C Protease

FMDV 3C Protease Type A10 (PDB code 2j92)

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Klump, W., O. Marquardt, and P.H. Hofschneider, Biologically active protease of foot and mouth disease virus is expressed from cloned viral cDNA in Escherichia coli. Proc Natl Acad Sci U S A, 1984. 81(11): p. 3351-5.

Grubman, M.J., M. Zellner, and J. Wagner, Antigenic comparison of the polypeptides of foot-and-mouth disease virus serotypes and other picornaviruses. Virology, 1987. 158(1): p. 133-40.

Vakharia, V.N., et al., Proteolytic processing of foot-and-mouth disease virus polyproteins expressed in a cell-free system from clone-derived transcripts. J Virol, 1987. 61(10): p. 3199-207.

Grubman, M.J. and B. Baxt, Translation of foot-and-mouth disease virion RNA and processing of the primary cleavage products in a rabbit reticulocyte lysate. Virology, 1982. 116(1): p. 19-30.

5.ablanian, G.M. and M.J. Grubman, Characterization of the foot-and-mouth disease virus 3C protease expressed in Escherichia coli. Virology, 1993. 197(1): p. 320-7.

Ryan, M.D., G.J. Belsham, and A.M. King, Specificity of enzyme-substrate interactions in foot-and-mouth disease virus polyprotein processing. Virology, 1989. 173(1): p. 35-45.

Clarke, B.E. and D.V. Sangar, Processing and assembly of foot-and-mouth disease virus proteins using subgenomic RNA. J Gen Virol, 1988. 69 ( Pt 9): p. 2313-25.

Grubman, M.J., et al., Identification of the active-site residues of the 3C proteinase of foot-and-mouth disease virus. Virology, 1995. 213(2): p. 581-9.

Falk, M.M., et al., Foot-and-mouth disease virus protease 3C induces specific proteolytic cleavage of host cell histone H3. J Virol, 1990. 64(2): p. 748-56.

Belsham, G.J., G.M. McInerney, and N. Ross-Smith, Foot-and-mouth disease virus 3C protease induces cleavage of translation initiation factors eIF4A and eIF4G within infected cells. J Virol, 2000. 74(1): p. 272-80.

Strong, R. and G.J. Belsham, Sequential modification of translation initiation factor eIF4GI by two different foot-and-mouth disease virus proteases within infected baby hamster kidney cells: identification of the 3Cpro cleavage site. J Gen Virol, 2004. 85(Pt 10): p. 2953-62.

Devaney, M.A., et al., Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex. J Virol, 1988. 62(11): p. 4407-9.

Medina, M., et al., The two species of the foot-and-mouth disease virus leader protein, expressed individually, exhibit the same activities. Virology, 1993. 194(1): p. 355-9.

Li, W., et al., Cleavage of translation initiation factor 4AI (eIF4AI) but not eIF4AII by foot-and-mouth disease virus 3C protease: identification of the eIF4AI cleavage site. FEBS Lett, 2001. 507(1): p. 1-5.

Zhou, Z., et al., Foot-and-mouth disease virus 3C protease induces fragmentation of the Golgi compartment and blocks intra-Golgi transport. J Virol, 2013. 87(21): p. 11721-9.

Armer, H., et al., Foot-and-mouth disease virus, but not bovine enterovirus, targets the host cell cytoskeleton via the nonstructural protein 3Cpro. J Virol, 2008. 82(21): p. 10556-66.

Lawrence, P., E.A. Schafer, and E. Rieder, The nuclear protein Sam68 is cleaved by the FMDV 3C protease redistributing Sam68 to the cytoplasm during FMDV infection of host cells. Virology, 2012. 425(1): p. 40-52.

Wang, D., et al., Foot-and-mouth disease virus 3C protease cleaves NEMO to impair innate immune signaling. J Virol, 2012. 86(17): p. 9311-22.

Martinez-Salas, E. and E. Domingo, Effect of expression of the aphthovirus protease 3C on viral infection and gene expression. Virology, 1995. 212(1): p. 111-20.

Birtley, J.R., et al., Crystal structure of foot-and-mouth disease virus 3C protease. New insights into catalytic mechanism and cleavage specificity. J Biol Chem, 2005. 280(12): p. 11520-7.

Sweeney, T.R., et al., Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the beta-ribbon in proteolysis. J Virol, 2007. 81(1): p. 115-24.

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