Function
Fibronectin (Fn) is a glycoprotein which binds extracellular matrix components like integrin, collagen, fibrin and others. It is a component of cell adhesion[1].
Relevance
Fn is associated with wound healing. Fn is a potential marker for radiation resistance.
Disease
Overexpression of Fn1 is associated with lung cancer[2].
Structural insights
linked by S-S bond. Each monomer contains 3 types of modules: FnI, FnII and FnIII. Each module contains several numbered protein binding domains, i.e., FnI6-FnII1-2-FnI7-9 is the gelatin binding domain (GBD).
3D Structures of Fibronectin
Fibronectin 3D structures
