Function
Focal adhesion kinase (FAK) is involved in cellular adhesion. During apoptosis, FAK is cleaved into 2 fragments. The smaller fragment is associated with death signaling. For details on focal adhesion kinase or protein tyrosine kinase 2β (PTK2) see Molecular Playground/FAK[1].
Relevance
FAK is overexpressed in many tumor cells. Hence they are investigated as anti-tumor drug targets[2].
Structural insights
FAK ATP-binding site is the [3].
3D Structures of focal adhesion kinase
Focal adhesion kinase 3D structures