Formate dehydrogenase

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Formate dehydrogenase (FDH) catalyzes the reversible two-electron oxidation of formate to bicarbonate. The product electron is donated to either NAD+ in NAD-dependent FDH or to Mo-dependent FDH where the electron is donated to a Fe4S4 center and then to cytochrome. The Mo-dependent FDH-H from E. coli contains SelCys, Mo, molybdopterin guanosine dinucleotide (MGD) cofactor and Fe4S4[1].

  • NAD binding site in NAD-dependent formate dehydrogenase (2nad). Water molecules shown as red spheres.
  • Azide ion binding site.

3D structure of formate dehydrogenase

Formate dehydrogenase 3D structures


NAD-dependent formate dehydrogenase dimer complex with cofactor NAD and sulfate, 2nad

Drag the structure with the mouse to rotate

References

  1. ↑ Ferry JG. Formate dehydrogenase. FEMS Microbiol Rev. 1990 Dec;7(3-4):377-82. PMID:2094290

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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