G18secL03Tpc4

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3D Structures

OspA

OspB

OspC

Cristal Structure of OspC

OspC Electro Potentials

OspC Strain B31

OspC Strain N40

OspC Mutant


Notes and References
  1. Stewart PE, Thalken R, Bono JL, Rosa P. Isolation of a circular plasmid region sufficient for autonomous replication and transformation of infectious Borrelia burgdorferi. Mol Microbiol. 2001 Feb;39(3):714-21. PMID:11169111
  2. Pal U, Yang X, Chen M, Bockenstedt LK, Anderson JF, Flavell RA, Norgard MV, Fikrig E. OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands. J Clin Invest. 2004 Jan;113(2):220-30. PMID:14722614 doi:10.1172/JCI19894
  3. 3.0 3.1 3.2 3.3 3.4 3.5 3.6 D. Kumaran1, S. Eswaramoorthy1, B.J. Luft2, S. Koide3, J.J. Dunn1, C.L. Lawson1,4 and S. Swaminathan1. Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi.The EMBO Journal (2001) 20, 971 - 978 [1]
  4. 4.0 4.1 4.2 Brisson D, Dykhuizen DE. ospC diversity in Borrelia burgdorferi: different hosts are different niches. Genetics. 2004 Oct;168(2):713-22. PMID:15514047 doi:10.1534/genetics.104.028738
  5. Marconi RT, Samuels DS, Garon CF. Transcriptional analyses and mapping of the ospC gene in Lyme disease spirochetes. J Bacteriol. 1993 Feb;175(4):926-32. PMID:7679385
  6. Grab DJ, Lanners H, Martin LN, Chesney J, Cai C, Adkisson HD, Bucala R. Interaction of Borrelia burgdorferi with peripheral blood fibrocytes, antigen-presenting cells with the potential for connective tissue targeting. Mol Med. 1999 Jan;5(1):46-54. PMID:10072447
  7. Sharma A, Askari JA, Humphries MJ, Jones EY, Stuart DI. Crystal structure of a heparin- and integrin-binding segment of human fibronectin. EMBO J. 1999 Mar 15;18(6):1468-79. PMID:10075919 doi:10.1093/emboj/18.6.1468
  8. 8.0 8.1 8.2 8.3 D. Greenburg, M.S. Rowe. Brookhaven Scientists Determine Key Lime Disease Protein Structure.Brookhaven National Laboratory (2001)[2]
  9. 9.0 9.1 R.B. Cadiz, M. Crawford, R.B. LeFebvre, W.S Probert. Immunization with Outer Surface Protein (Osp) A, but Not OspC, Provides Cross-Protection of Mice Challenged with North American Isolates of Borrelia Burgdorferi. The Journal of Infectious Diseases 1997; Volume 175: 400-405. [3]
  10. Barbour AG, Travinsky B. Evolution and distribution of the ospC Gene, a transferable serotype determinant of Borrelia burgdorferi. MBio. 2010 Sep 28;1(4). pii: e00153-10. PMID:20877579 doi:10.1128/mBio.00153-10
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