Glucagon-like peptide 1 receptor
From Proteopedia
FunctionGlucagon-like peptide 1 receptor (GLP-1R) mediates the action of glucagon-like peptides (GLP-1) which are hormones involved in nutrient intake, gastrointestinal motility, islet hormone secretion, cell proliferation and apoptpsis[1]. RelevanceGLP-1R agonists are used in treatment of type 2 diabetes[2]. GLP-1 analogues can cross the brain-blood barrier and stimulate the GLP-1R in the brain. This stimulation is affecting mitochondrial functioning, protein aggregation, neuroinflammation, synaptic plasticity, learning and memory in models of Parkinson Disease and Alzheimer Disease[3]. It is a member of the glucagon receptor family of G protein-coupled receptors. Structural highlightsThe 3D structure of the complex of GLP-1R and GLP-1 shows the GLP-1 peptide as a kinked helix. The ampiphilic GLP-1 helix shows and interactions with GLP-1R on opposite faces[4]. . See also: 3D structures of glucagon-like peptide receptorGlucagon-like peptide receptor 3D structures References
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