Granzyme

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Structure of glycosylated human granzyme B (green) complex with pentapeptide inhibitor (magenta) and Zn+2 ions (grey) (PDB entry 1iau)

3D structures of granzyme

Updated on 04-April-2019

References

  1. Bots M, Medema JP. Granzymes at a glance. J Cell Sci. 2006 Dec 15;119(Pt 24):5011-4. PMID:17158907 doi:http://dx.doi.org/10.1242/jcs.03239
  2. Lieberman J. Granzyme A activates another way to die. Immunol Rev. 2010 May;235(1):93-104. doi: 10.1111/j.0105-2896.2010.00902.x. PMID:20536557 doi:http://dx.doi.org/10.1111/j.0105-2896.2010.00902.x
  3. Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC. Granzyme B: a natural born killer. Immunol Rev. 2003 Jun;193:31-8. PMID:12752668
  4. Waterhouse NJ, Trapani JA. H is for helper: granzyme H helps granzyme B kill adenovirus-infected cells. Trends Immunol. 2007 Sep;28(9):373-5. Epub 2007 Sep 4. PMID:17766182 doi:http://dx.doi.org/10.1016/j.it.2007.08.001
  5. Bovenschen N, Quadir R, van den Berg AL, Brenkman AB, Vandenberghe I, Devreese B, Joore J, Kummer JA. Granzyme K displays highly restricted substrate specificity that only partially overlaps with granzyme A. J Biol Chem. 2009 Feb 6;284(6):3504-12. doi: 10.1074/jbc.M806716200. Epub 2008, Dec 5. PMID:19059912 doi:http://dx.doi.org/10.1074/jbc.M806716200
  6. de Poot SA, Bovenschen N. Granzyme M: behind enemy lines. Cell Death Differ. 2014 Mar;21(3):359-68. doi: 10.1038/cdd.2013.189. Epub 2014, Jan 10. PMID:24413154 doi:http://dx.doi.org/10.1038/cdd.2013.189
  7. Rotonda J, Garcia-Calvo M, Bull HG, Geissler WM, McKeever BM, Willoughby CA, Thornberry NA, Becker JW. The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1. Chem Biol. 2001 Apr;8(4):357-68. PMID:11325591

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