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The Rohs Lab at USC and Protein-DNA Institute at La Cañada High School

Welcome, students, fellow researchers and educators! Welcome to your home page for the joint structural biology initiative between the Rohs Lab at the University of Southern California (USC) and the Protein-DNA Institute at La Cañada High School (LCHS), hosted on the Proteopedia web resource. The goal of this website is to provide a cyber-infrastructure for the use of graphic visualization tools in integrated educational and research activities focused at structural aspects of proteins and nucleic acids. You will notice that this is not a regular webpage. If you scroll down a bit, you will find that there are interactive 3D structures of protein-DNA complexes on this page. You can even trigger animations by clicking on green hyperlinks in the text when you find them. These green hyperlinks will change the orientation and representation of the 3D structure in order to illustrate a point made in the related scientific publication. The best part is that it is easy to create your own page with an interactive 3D structure and green links, and that is what you will be doing to present your findings! Feel free to also explore other pages in Proteopedia that are not related to USC-LCHS. Proteopedia is a collaborative 3D encyclopedia of proteins and other biomolecules, and you will find many interesting molecules described in interactive detail.

Example: Readout of DNA minor groove shape is the molecular basis for Hox specificity

Hox protein Scr (blue) and its cofactor Exd (green) bind to the Scr-specific DNA target (PDB entry 2r5z)

Drag the structure with the mouse to rotate

Example: Hoogsteen base pairs modulate shape of p53-DNA binding site

Tumor suppressor p53 binds as a tetramer to DNA targets (Biological Assembly of PDB entry 3kz8)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Eran Hodis, Remo Rohs

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