Guanine nucleotide dissociation inhibitor

From Proteopedia

Structure of mouse guanine nucleotide dissociation inhibitor (green) complex with GTPase RhoA (grey), geranyl geran, phosphoaminophosphonic acid-guanylate ester and Mg+2 ion (green) (PDB code 4f38). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Guanine nucleotide dissociation inhibitor or Rho GDP-dissociation inhibitor (GDI) bind to GDP-bound Rho (RhoGDI) and Rab small GTPase maintaining it in an off-stage and preventing the GTPase localization to the membrane[1]. Relevance Levels of RhoGDI are significantly low in tumor tissues[2].

3D structures of guanine nucleotide dissociation inhibitor

Updated on 25-April-2023

References

1. ↑ Peter F, Nuoffer C, Pind SN, Balch WE. Guanine nucleotide dissociation inhibitor is essential for Rab1 function in budding from the endoplasmic reticulum and transport through the Golgi stack. J Cell Biol. 1994 Sep;126(6):1393-406. PMID:8089173
2. ↑ Jiang WG, Watkins G, Lane J, Cunnick GH, Douglas-Jones A, Mokbel K, Mansel RE. Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers. Clin Cancer Res. 2003 Dec 15;9(17):6432-40. PMID:14695145