Haptoglobin receptor

Function

Haptoglobin receptor or Iron-regulated surface determinant protein H (IsdH) is part of the iron-regulated surface determinant system that captures heme from the host hemoproteins. IsdH binds haptoglobin (Hp) which removes hemoglobin (Hb) from the blood by forming Hp-Hb complex. IsdH contains multiple NEAT (Near Transporter) domains which bind proteins and heme^[1]. For more details see Molecular Playground/Hemoglobin-Haptoglobin Complex.

• . (PDB code 3szk)
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