Human Fab PG16

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PDB ID 3mug

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References

  1. 1.0 1.1 Robert Pejchal, Laura M. Walker, Robyn L. Stanfield, Sanjay K. Phogat, Wayne C. Koff, Pascal Poignard,Dennis R. Burton, and Ian A. Wilson. Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. Proc Natl Acad Sci U S A. 2010 June 22; 107(25): 11483–11488. PMCID: PMC2895122.
  2. Al-Lazikani B, Lesk AM, Chothia C. Standard conformations for the canonical structures of immunoglobulins. J Mol Biol. 1997 Nov 7;273(4):927-48. PMID:9367782 doi:10.1006/jmbi.1997.1354
  3. 3.0 3.1 3.2 Pancera M, McLellan JS, Wu X, Zhu J, Changela A, Schmidt SD, Yang Y, Zhou T, Phogat S, Mascola JR, Kwong PD. Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1. J Virol. 2010 Aug;84(16):8098-110. Epub 2010 Jun 10. PMID:20538861 doi:10.1128/JVI.00966-10


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